Amaechi described Wike's allegation that he created a new cult group in Rivers State as "gubernatorial madness".
The State Governor, Nyesom Wike had on Monday, May 22, accused Amaechi, his predecessor, of founding the cult group to frustrate the efforts of his government ahead of the 2019 general election.
But Amaechi described the allegation as "gubernatorial madness", stressing that Wike will face the wrath of the law when he leaves office.
The minister also said the Governor will ultimately face the wrath of God, from whom he (Wike) has no constitutional immunity protection.
A statement issued by Amaechi's media office on Tuesday and obtained by Premium Times was entitled "Again, Governor Wike Goes Mad."
It said Wike has continued to display "his exclusive and uncommon strand of gubernatorial madness when he attempted to link his mentor, benefactor and predecessor Rt. Hon. Chibuike Rotimi Amaechi, as a sponsor of cultists in Rivers State."
The statement said Wike's latest allegation against Amaechi fits the Governor's "style and pattern of distraction and obfuscation- tell a lie to distract, and then tell another lie and another lie to distract our attention from the previous lie, creating an endless web of lies, confusion and deception."
"Sadly, this is the kind of irresponsible, reckless, disgraceful garrulous, scallywag conman that presides over the affairs of Rivers State."
It added that Wike is an attention seeker and always wanting to be seen in the media to be "exposing and fighting" Amaechi.
"However, we will burst his bubble this time and will not indulge him or dignify his crass stupidity," it said.
"If he has any sense, Wike ought to know by now that no one takes him seriously anymore, especially whenever he makes those cooked-up vile, malicious allegations against the Minister of Transportation, Rotimi Amaechi.
"This his new concocted story is not any different from the previous numerous false allegations he has made against Amaechi," the statement said.
Wike had previously accused Amaechi of being the owner of the $43 million found in an Ikoyi, Lagos apartment by the Economic and Financial Crimes Commission (EFCC).
The Governor alleged that Amaechi stole the money from Rivers State coffers and kept it in the apartment.
It later turned out that the money belonged to the National Intelligence Agency (NIA).
Wike has been quiet on the allegation since the ownership of the cash haul was established by the suspended NIA boss, Ayodele Oke.