NASA reached a milestone on Friday when two Americans ventured out of the International Space Station to replace a power controller: The astronauts, Jessica Meir and Christina Koch, had undertaken the first all-female spacewalk.

NASA reached a milestone on Friday when two Americans ventured out of the International Space Station to replace a power controller: The astronauts, Jessica Meir and Christina Koch, had undertaken the first all-female spacewalk.

CLEVELAND — A mayor of a small West Virginia city brought to its knees by opioids and representatives of large cities and counties left reeling by the epidemic are gathering in federal court here Friday to sit side by side with chief executives from the country’s largest drug distributors. Along with four state attorneys general, they were summoned by Judge Dan A. Polster, who is trying to wrest a far-reaching, last-minute agreement to resolve thousands of lawsuits before the start of the first trial Monday.