Handler shared two photos, showing herself half naked, rocking a black thong as she backed the camera in a bid to show off the insulting message she had written across her back and butt.
The trim comedian had the words "Trump is a butt hole" written right across her back and butt, as she turned slightly, to smile at the camera.
On one photos, Handler commented:
"A germane tweet. I mean this with the utmost disrespect."
On the second photo, she commented:
"Sometimes we swim above water and sometimes we swim on the sea floor. I’ll meet you wherever you are."
Handler's diss is the second in recent time, after she launched a very nasty attack on Trump yesterday, posting a photo of herself cleaning the streets of Mexico on her Instagram [April 3] while on set of her show, with what looks like a mopping stick which had some striking resemblance to the Republican Presidential hopeful.
Handler only joins a long list of celebrities - Chris Brown, Jennifer Lopez, Shakira and Tyrese who have condemned the US Presidential candidate over his "strange" policies and speeches at campaign grounds.
Watch Donald Trump in video clip below: