Accutane: A Controversial Drug Chris Pine Used to Fix His Acne Problem

While promoting his new television show I Am the Night earlier this week, Pine was the latest male celeb to (joining the likes of skin-gods before him and ). While his first instinct was to brush it off and thank a deep sauna session, he did finally confess to having terrible acne problems as a teenager, crediting a controversial treatment, something much stronger than night cream or exfoliation with his glow up. Ive been on Accutane, he said. Its the miracle drug of all time.

*Record scratch* The A-list actor admitted that his skin problems were so bad that he needed the worlds most powerful acne medication to get through it.

*Double record scratch* But Accutane is a super intense, potentially dangerous drug, right?

Before you start sprinting out to buy Accutane (which you would need a prescription for anyway), theres a lot you need to know about it. Many people refer to it as the last-resort of acne treatments, meaning that its so powerful, it should only be used in the most extreme cases. And while we commend Pine for being honest about his past (presumably without some sort of sponsorship deal, ), Accutane is not for everyone.

I called up Joshua Zeichner, MD, Director of Cosmetic and Clinical Research, Dermatology, at Mount Sinai Hospital in New York City, to find out everything you need to know about Accutane. While the miracle drug wont increase your chances of a lip-lock scene with Gal Gadot, if its right for you, it might help you get a little closer to leading man skin.

WTF is Accutane, Anyway?

Accutane is the brand name of a medication called Isotretinoin, says Dr. Zeichner. The brand-name product was taken off the US market in 2009, however several generic versions are currently available. So if you ask your doctor for Accutane, know that you probably wont actually get Accutane. However, that doesnt mean the versions on the market today are any less intense. It is perhaps the single most effective treatment that we have for severe acne, he says.

How Does It Work?

Acne is caused by four main factors, but most over the counter treatments only target one or two of them-thats the key to Accutanes efficacy. Isotretinoin is a derivative of vitamin A that decreases oil production in the skin, reduces inflammation, prevents cells from sticking together within the pores [buildup], and lowers levels of acne-causing bacteria, says Dr. Zeichner. It is the only medication we have that addresses all of the major underlying causes of acne. Many claim that Isotretinoin can even help treat acne scars.

Who Is Accutane Best For?

Isotretinoin is FDA-approved for anyone over the age of 12 and is indicated for people who have severe acne and those who have physical (or emotional) scars, says Dr. Zeichner. Those emotional scars? We know that acne is much more than skin-deep and can have a significant effect on emotional well-being, he says. Most importantly, and the reason why its sometimes thought of as a last resort, is that its especially useful for people who have been resistant to other, more traditional, treatments like topical medications and antibiotics.

How Long Do You Have to Take It?

The exact treatment plan varies on a variety of factors, including your gender, weight, and severity of acne. Patients take the [oral] medication daily, generally for five to seven months, says Dr. Zeichner. While most patients only go through one round of treatment, some extreme cases require two. If more than one round of treatment is needed, doctors recommend waiting about two months between them.

How Long Do The Results Last?

Patients almost universally experience permanent improvements in the skin, says Dr. Zeichner. We cannot promise that they will never get a pimple again, but the skin is significantly better after treatment.

What Do I Have to Keep In Mind When Im Using It?

The most common side effects are dryness of the skin and the lips, says Dr. Zeichner, which means that you may need to ramp up your . It can also make your skin more sensitive, so the advises using daily sun protection and avoiding tanning beds. They also advise against donating blood during treatment (and 30 days after your last pill) and not waxing your body hair for at least six months after youre finished (since it can cause permanent scarring).

Does It Have A Lot of Other Side Effects?

The conversation around Accutane is riddled with controversy, mainly because of its other potential side effects. Rarely, it can affect the liver, so monthly blood tests are necessary [when taking the medication], says Dr. Zeichner. Some patients can develop headaches and blurry vision. Confusion can come from word-of-mouth and misinformation. There is a questionable association with depression and mood changes, which have largely been disproven, he says. It has also been associated with Ulcerative Colitis, a form of Inflammatory Bowel Disease (IBD), but a disproved that.

I Heard It Causes Infertility. Is That True?

that it does not have a negative effect on male fertility. It can, however, have an effect on women. It can cause birth defects, so women of childbearing potential must be on two forms of contraception, says Dr. Zeichner.

Someone Told Me Accutane Can Kill You. What Gives?

Death by Accutane is a myth, probably started by a 2010 court case where a man claimed the drug gave him IBD which led to the removal of his colon. Not only was the verdict in his favor eventually reversed, but as Dr. Zeichner noted, the 2014 French study disproved a connection between the two.

How Do I Know If It Will Work For Me?

It is important to speak with your dermatologist about the ideal regimen for you, says Dr. Zeichner. Despite having many potential side effects, when properly monitored by your dermatologist, isotretinoin is a safe and effective medication that I use in my practice daily. Like other prescription medications, there is a reason you have to get Accutane from a doctor. But if you have severe acne, its worth having the conversation