Lakers star player LeBron James could not save the Lakers as they could not create the momentum which saw them sweep aside the Miami Heat in their last fixture.
Houston have struggled for consistency this season but veteran Chris Paul has returned to full fitness and was key for the Rockets against the Lakers.
The Rockets won the first and second quarter (29-24, 33-32), the Lakers however took the the third quarter but could not not outscore the Rockets.
Harden recorded a triple double with 50 points, 11 assists and 10 rebounds with help from Clint Capela who contributed 16 points.
Top performers for the Lakers were LeBron James with 29 points while Kyle Kuzma added 24 points.
The Phoenix Suns recorded a shock 99-89 victory over the high flying Dallas Mavericks with TJ Warren contributing 30 points for the home side.
LaMarcus Aldridge scored 27 points and Rudy Gay added 21 points as the San Antonio Spurs beat the Los Angeles Clippers 125-87.
The Orlando Magic left it late but beat the Chicago Bulls 97-91 in Mexico City, Nikola Vucevic with 26 points and 10 rebounds .