The reigning four-time constructors' championship winners have claimed wins at three of the past five races at Silverstone, beginning with Vettel's victory in 2009.
Vettel, the four-time defending champion, is looking forward to Sunday despite his struggles this Formula One season.
The German sits fifth in the drivers' standings after two retirements in his past three races.
"This race has an extra element as it's so close to the factory and a lot of the staff who work so hard on the car will be watching from the grandstands with their families," Vettel said.
"I hope we can get a good result for them.
"As the factory is only about half an hour or so from the track a lot of the race team live nearby and can sleep in their own beds for the weekend which surely is a nice thing for them.
"I have good memories of Silverstone, the best must be winning there in 2009 and Mark (Webber) won there in 2010 and 2012 so we have a good record at the track."
Vettel's team-mate Daniel Ricciardo, who is behind Mercedes duo Nico Rosberg and Lewis Hamilton in the standings, said it was a tougher track than it looked.
"The more I drive it, the more I also enjoy the new section because it creates more chances for overtaking and it's not as straightforward as it looks," the Australian said.
"I'm looking forward to my first race with Infiniti Red Bull Racing this year at Silverstone, I know a lot of the guys are going to be watching at the track so I'll be going at it for a good result."