It came after South Africa's ruling African National Congress decided to remove Zuma from his role on Monday.
Jacob Zuma has resigned as president of South Africa.
The resignation came after the African National Congress (ANC), the country's ruling party, decided to remove the president from his role on Monday.
In a televised speech to the nation on Wednesday night, Zuma said he had "come to the decision to resign as president of the republic with immediate effect."
"Even though I disagree with the decision of the leadership of my organization, I have always been a disciplined member of the ANC," he added.
"No life should be lost in my name. And also the ANC should not be divided in my name."
Earlier on Wednesday, Zuma called the ANC's efforts to oust him "very unfair," but gave in and left office just hours later.
Zuma, who became president in 2009, has faced allegations of corruption, money laundering, and fraud.
He served as the head of ANC from 2007 to December 2017. The party is currently being led by Deputy President Cyril Ramaphosa, who is expected to succeed Zuma as President.