The actor's manager confirmed that he died from a heart disease in a statement to reporters.
His manager, Emily Gerson Saines, confirmed the news of his passing in a statement to the Hollywood Reporter.
"Nelsan has passed away after complications with heart failure.
"He was a great talent, and his words and presence will be forever missed," she said.
One of his "True Blood" co-stars, Kristin Bauer, who seemed absolutely gutted about the development mourned the deceased in a heartfelt Instagram post.
She wrote, "One of the sweetest most talented men I've ever met.
"A terrible loss for all of us. Rest In Peace Nelsan. You will be missed. I don't know how else to put words to this terribly sad news..."
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The deceased, who featured in the "True Blood" hit series for the seven seasons which the programme ran also had other famous appearances in "The Help".
His most recent appearance in a television programme was in CBS "Elementary" show.