The Sydney-born actor is suing an Australian publisher for articles in 2015 that claimed she lied to advance her Hollywood career.
On day one of a defamation trial in Victoria state's Supreme Court, Wilson's barrister Matthew Collins told the jury that Bauer Media "tore down an Australian star to sell magazines".
"They refused to let the facts get in the way of a good story," he said, The Age newspaper reported.
"This defendant knows that what it wrote was simply false."
The Sydney-born actor, who starred in "The Bridesmaids" and "Pitch Perfect", is suing the media group for articles in 2015 that claimed Wilson lied about her name, age and background in order to advance her Hollywood career.
The publisher owns magazines Woman's Day, Australian Women's Weekly and OK Magazine.
Collins said the actor, who flew to Melbourne from the United States for the trial, had been robbed of acting opportunities as a result of the stories.
"The phone just stopped ringing," he said.
The trial is expected to run for three weeks and include testimony from Wilson's family.