The death of Emiley Sanchez de la O, 40, leaves only one survivor from the May 18 crash of the Boeing 737 operated by national carrier Cubana de Aviacion.
Mailen Diaz, 19, remains hospitalized with a guarded prognosis.
The only other survivor, Gretell Landrove, 23, died on Monday.
They were on a domestic flight to the eastern city of Holguin, where most of the passengers were from, when the 39-year-old plane went down.
It was leased from Global Air, a Mexican company, and carried 113 passengers and crew.
The dead included six Mexican crew members and five foreign passengers: two Argentines, one Mexican and two passengers from Western Sahara.
An investigation into the country's worst air disaster in decades is expected to take months.
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