Liverpool vs Everton preview, odds, prediction, team news and lineups

The Reds are in scintillating form with five straight wins across all competitions, while Everton have shown resilience with just one defeat in their last four league games.

Liverpool have dominated recent derbies at Anfield, winning the last three, but Everton will take confidence from their solid start to the season under David Moyes.

The fierce Merseyside Derby returns as Premier League leaders Liverpool host local rivals Everton at Anfield on September 20, 2025, at 12:30.

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This highly anticipated fifth-round clash will be officiated by Darren England, with the Reds looking to maintain their perfect start to the season against an Everton side sitting in sixth place.

The historic rivalry between these two clubs, separated by just a few miles across Liverpool, adds extra significance to what promises to be an intense Premier League encounter.

Liverpool (4-2-3-1, Arne Slot)
Goalkeeper: Alisson Becker (1)
Defence: Dominik Szoboszlai (8), Ibrahima Konate (5), Virgil van Dijk (4), Milos Kerkez (6)
Midfield: Ryan Gravenberch (38), Alexis Mac Allister (10), Mohamed Salah (11), Florian Wirtz (7), Cody Gakpo (18)
Forward: Hugo Ekitike (22)
Absent: Stefan Bajcetic (43), Curtis Jones (17)

Everton (4-2-3-1, David Moyes)
Goalkeeper: Jordan Pickford (1)
Defence: Jake O'Brien (15), James Tarkowski (6), Michael Keane (5), Vitaliy Mykolenko (16)
Midfield: James Garner (37), Idrissa Gana Gueye (27), Carlos Alcaraz (24), Kiernan Dewsbury-Hall (22), Jack Grealish (18)
Forward: Beto (9)
Absent: Jarrad Branthwaite (32)

The recent history between these Merseyside rivals has been dominated by Liverpool, who have won three of the last five meetings. The most recent encounter saw Liverpool edge Everton 1:0 at Anfield in April 2025, with Diogo Jota scoring the decisive goal in the 57th minute.

Their previous clash at Goodison Park in February 2025 ended in a thrilling 2:2 draw, with James Tarkowski scoring a 90th-minute equalizer after Mohamed Salah had put Liverpool ahead. Everton did claim a notable 2:0 victory at Goodison Park in April 2024, with goals from Jarrad Branthwaite and Dominic Calvert-Lewin, but Liverpool have been particularly strong at Anfield, winning their last three home derbies.

Liverpool enter this derby in sensational form, having won all five of their matches across all competitions this season. They began their Premier League campaign with an impressive 4:2 victory over AFC Bournemouth (on 15.08.2025), followed by a 3:2 away win at Newcastle United (on 25.08.2025) where Cody Gakpo provided two assists.

The Reds continued their winning streak with a 1:0 triumph over Arsenal (on 31.08.2025) and a 1:0 away victory against Burnley (on 14.09.2025).

Most recently, they defeated Atletico Madrid 3:2 in their Champions League opener (on 17.09.2025).

Everton have been in decent form themselves, with two wins, one draw, and one loss in the Premier League. After starting with a 1:0 defeat at Leeds United (on 18.08.2025), they bounced back with a 2:0 win over Brighton & Hove Albion (on 24.08.2025) with Jack Grealish providing two assists.

They progressed in the EFL Cup with a 2:0 victory against Mansfield (on 27.08.2025) before securing an impressive 3:2 away win at Wolves (on 30.08.2025) and drawing 0:0 with Aston Villa (on 13.09.2025). Liverpool currently top the Premier League with 12 points, while Everton sit sixth with 7 points.