In the midst of a strong performance, Nuno Mendes was forced off the pitch early in the second half of the Portugal-Spain match, around the 55-minute mark, seemingly due to a muscle issue. Manager Roberto Martínez opted to replace him with Nélson Semedo.
While challenging Lamine Yamal in a one-on-one duel, the Portuguese international stretched to clear an opponent's cross, and this proved to be his final action in the Round of 16 clash. Earlier in the first half, he had rattled the crossbar with a powerful shot after a deflection off Porro.
Towards the end of this season with PSG, Nuno Mendes was carefully managed by Luis Enrique. However, he recovered in time to play in the UEFA Champions League final and celebrate winning his second European title on the field.