Omotola was born in Lagos on February 7, 1978 to a family of five who hails from Ondo state, she studied Estate Management from the Yaba College of Education.

Her first acting role was in the 1995 movie, Venomof Justice, where she was given the lead role in the movie, and that set the stage for her flourishing career in Nollywood.

She was the first African celebrity to receive over one million likes on her Facebook page, In 2013, she was listed on the list of 100 most influential people in the world by TIME Magazine.

Omotola, became a UnitedNationsWFP, (WorldFood Programme), Ambassador in 2005, going to missions in Sierra Leone and Liberia. She has been active in the Walk the World project and participated in the WalktheWorldcampaign in Liberia with PresidentEllenSirleaf-Johnson.

Omotola who is a chief in her community, runs her own NGO called the OmotolaYouthEmpowermentProgramme, (OYEP), which brings hundreds of youths together for theEmpowermentWalk and Convention.