Fenerbahce want Musa and Vardy to replace Emenike, Sow and Van Persie who are expected to leave.
After a frustrating year with Leicester City, Musa is expected to leave England with Fenerbahce leading the race to sign him.
While his teammate Vardy seem settled at Leicester City, Fenerbahce are reportedly planning to sign him also.
According to Turkish news platform DHA, Fenerbahce are in dire need of strikers following the reported imminent exit of Emmanuel Emenike and Moussa Sow.
Former Manchester United and Arsenal striker Robin van Persie is also expected to leave.
Fenerbahce according to the report have already made moves to sign Musa who had a poor debuts season with Leicester City.
The 24-year-old Nigeria international scored just four goals in 31 appearances for Leicester City who splashed £16million to sign him in the summer of 2016.
For Vardy, Fenerbahce would have a lot of convincing to do before they can sign the striker who shrugged off a poor start of last season to score 18 goals for club and country.