Staal was hit by Sabres defenseman Josh Gorges during the third period and will find out how long he will be sidelined on Thursday.
Drew Stafford and Tyler Ennis scored second-period goals and Jhonas Enroth made 35 saves for the shutout.
Goaltender Sergei Bobrovsky stopped 30 shots as the Columbus Blue Jackets overcame the Pittsburgh Penguins 2-0.
Jonathan Toews' overtime goal was enough for the Chicago Blackhawks to edge the Detroit Red Wings 2-1.
Drayson Bowman's goal with 48 seconds remaining helped the Montreal Canadiens beat the Boston Bruins 3-2.
The Toronto Maple Leafs crushed the Philadelphia Flyers 4-0 and Jonathan Marchessault's double saw the Tampa Bay Lightning beat the Nashville Predators 4-2.
The Vancouver Canucks split their two matches against the San Jose Sharks.
Linden Vey scored and set up two in a 4-2 Canucks win and Joe Thornton's brace saw the Sharks to a 5-2 victory.
The Arizona Coyotes comfortably beat the Anaheim Ducks 4-0.
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