Enyimba are the only representatives from the NPFL that progressed to the group stage of the CAF Confederation Cup.
The Peoples Elephants progressed to the group stage of the CAF Confederation Cup after they saw of South African side Bidvest Wits with an aggregate scoreline 1-1 and qualified on away goals.
Other Nigeria representatives such as Akwa United, Plateau United and MFM FC all lost out at the last round of qualification.
They will face Willamsville of Ivory Coast, Club Athletique of Congo and Malian side Djoliba who knocked out MFM.
History of Enyimba in CAF Confederation Cup
Enyimba are Nigeria's most successful club side on the continent after a consecutive triumph in the CAF Champions League in 2003 and 2004.
No Nigerian team has won the CAF Confederation Cup in its present format and the Peoples Elephants will aim to be the first NPFL side since Dolphins FC in 2005 to get to the final.
Enyimba's group stage fixtures
At home vs Djoliba Friday, May 4
Away vs Club Athletique Tuesday, May 15
At home vs Williamsville Tuesday, July 17
Away vs Williamsville Friday, July 17
Away vs Djoliba Friday, August 17
At home vs Club Athletique, Tuesday, August 28.