The Spanish club announced his passing on Friday in a statement posted on its website.
Former Barcelona Boss Tito Vilanova Dies Aged 45
Former Barcelona Manager Tito Vilanova has died of throat cancer at the age of 45.
"It is with sadness that Barcelona must announce that Francesc 'Tito' Vilanova has died today at the age of 45
"The death of our former coach occurred this afternoon when he could not overcome this disease which he had battled since 2011," the statement read.
Vilanova who took over from Present Bayern Munich manager Pep Guardiola was only in charge for one season during which he won the Spanish La Liga.
He was admitted to hospital last week after fighting a recurring tumor in a saliva gland and died this afternoon.
He is survived by his wife, Montse Chaure, and their two children.
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