Among the most significant changes are the creation of a new ownership committee and the pending hire of a new disciplinary officer.
The 32 teams unanimously signed off the policy's revisions, with commissioner Roger Goodell saying the new policy is "significantly strengthened".
He made a point to emphasise that it pertains to not only players, but all league and team employees.
"It's comprehensive, it's strong, it is tough and it is better for everyone associated with the NFL," he said during brief comments in Dallas on Wednesday.
One area the NFL Players Association will not be pleased with is Goodell's continued role in handing down discipline. The union wanted outside representatives to hear cases, such as the judge who overturned Ray Rice's recent suspension.
"We thought about having an arbitrator, but that [Rice] is a one-off situation," said New England Patriots owner and committee member, Robert Kraft.
"People are trying to do a good job, but they can compromise or water down what our best interests are. We feel strongly about that."
The NFLPA has strong feelings, too - in the opposite direction.
"Our union has not been offered the professional courtesy of seeing the NFL's new personal conduct policy before it hit the presses," the union's statement read. "Their unilateral decision and conduct today is the only thing that has been consistent over the past few months."
The new policy, aimed at improving upon punishment and education around domestic violence, sexual assault and violent crimes, will provide NFL-funded counseling and services for victims, families and violators.
No small factor will be the involvement of independent investigators from within league, which will complement the work of police, at the very least.
This year, Goodell announced a six-game suspension for first-time domestic violence offenders. That "baseline" will also include violations of assault, battery, dating violence, child abuse or other forms of family violence.
The commissioner will hire an executive with a criminal justice background to issue initial discipline, filling the position of Special Counsel for Investigations and Conduct. He or she will oversee the NFL's investigations and mete out the discipline based on the new personal conduct policy.
It is little different than the current collective bargaining agreement in which a league executive serves in a similar role.