The Wallabies will renew their rivalry with England at Suncorp Stadium this weekend, eight months from their rout of the 2015 Rugby World Cup hosts.
Australia crushed the then Stuart Lancaster-led England 33-13 in October to reach the quarter-finals but the English have since gone on to win the Six Nations Grand Slam for the first time in 13 years under former Wallabies coach Eddie Jones.
"It's a long time ago now [since the World Cup]. A lot has happened since then," Moore said on Friday as he prepares for his 103rd Test.
"We haven't played as a front row yet this year so this is our first opportunity to go out there and show what it means to us.
"First scrum's always important in every game. Tomorrow will be no different."
There are three debutants in Australia's squad for the clash in the Queensland capital, with Rory Arnold, Samu Kerevi and Dane Haylett-Petty included by coach Michael Cheika.
As for touring England, George Ford has been replaced by Owen Farrell at fly-half.
Marland Yarde and Luther Burrell have also been named in the starting line-up ahead of Jack Nowell and Manu Tuilagi, who missed the trip Down Under due to a hamstring injury, while there was no room for hopeful Ben Te'o as Jones attempts to mastermind England's first Test series win in Australia.
"It [beating Australia] would be really massive. It would make everyone in the world stand up and say: 'Well maybe England are doing something different now'," the Australian coach said.
"The game's going to go to a different level on Saturday night. Australia is going to be absolutely rampant. This is the first Test they've played with expectations on them. We know they're going to be absolutely breathing fire.
"Australia are by far the best side we're going to have played and we'll find out where we're at. Here goes, let's swing the bat and see how we go."