Saia Fainga'a will make his first Australia start in four years in Saturday's Rugby Championship clash against South Africa at Newlands.
The 27-year-old is one of three changes from the side that beat Argentina 32-25 on September 13, with vice-captain Adam Ashley-Cooper and Joe Tomane also coming back into the fold.
Fainga'a got the nod to start ahead of Reds team-mate James Hanson. while Ashley-Cooper comes in for Peter Betham and Tomane replaces Rob Horne.
It is the return of Fainga'a which has been most surprising, with his last start for the national team coming in the 25-16 win over Wales in November 2010.
Australia will attempt to secure their first win against South Africa in Cape Town for 22 years and coach Ewen McKenzie believes set-pieces will be crucial.
McKenzie said: "The set-piece is always an important area of focus for us, even more so when you play South Africa, and we know the outcome of the scrum and line-out will be crucial to the final result.
"We've been really impressed with the effort [Fainga'a] has put in off the field recently, and he'll be determined to make the most of this opportunity."
Prop Benn Robinson has been added to the replacement at the expense of Pek Cowan.
Australia team: 15. Israel Folau, 14. Adam Ashley-Cooper, 13. Tevita Kuridrani, 12. Matt Toomua, 11. Joe Tomane, 10. Bernard Foley, 9. Nick Phipps; 8. Ben McCalman, 7. Michael Hooper [captain], 6. Scott Fardy, 5. Rob Simmons, 4. Sam Carter, 3. Sekope Kepu, 2. Saia Fainga'a, 1. James Slipper.
Replacements: 16. James Hanson, 17. Benn Robinson, 18. Ben Alexander, 19. James Horwill, 20. Scott Higginbotham, 21. Nic White, 22. Kurtley Beale, 23. Rob Horne.