Runaway MotoGP World Championship leader Marc Marquez could equal Mick Doohan's 17-year record with victory at Misano this weekend.
The Repsol Honda man has been virtually unstoppable so far this season, winning 11 of the 12 races to date to open up an 89-point lead over his nearest challenger, team-mate Dani Pedrosa.
After winning the first 10 races in succession, reigning world champion Marquez's dominance was briefly interrupted by a win for Pedrosa in Brno, before normal service was resumed last time out at Silverstone.
Should Marquez seal a 12th success of the campaign in San Marino, he will draw level with the mark set by Doohan - who also rode for Repsol Honda - in 1997.
And the Spaniard is hoping for perfect conditions as he aims to recreate history.
"It was nice to be back on the top step of the podium in Silverstone, the team did a great job the whole weekend," Marquez said.
"Now we head to Misano which is a smaller and slower track compared to others on the calendar.
"We will have to work hard from Friday to get the setup on the bike just right, to suit the demands on braking at this twisty track and let's hope the weather is also nice."
Attempting to stop Marquez in his tracks will be Yamaha's Jorge Lorenzo, victor at Misano in each of the last three years, as well as Pedrosa, who last won in San Marino in 2010.
"I'm looking forward to Misano this weekend," said Pedrosa. "There is always a nice crowd over the three days and a good atmosphere with the Italian fans.
"Hopefully we'll have good weather from the Friday and get things going in the right direction.
"It's a short lap but intense with many overtaking points and it's quite bumpy, so set up is key. Let's hope for an exciting race."