Out of form with the Cricket World Cup less than a month away, India will be desperate for a win against Australia.
Australia are likely to experiment in their clash against India on Monday, with their place in the tri-series final already secured.
Darren Lehmann's team are top of the table after three wins in as many matches in good signs ahead of the Cricket World Cup.
The coach said he would make changes, with opener David Warner returning after missing two outings with a hamstring injury.
Mitchell Johnson is also close to coming back, while Shane Watson could also return on Australia Day.
Changes for the clash in Sydney could give India an opportunity to get back into some form.
India have lost to both Australia and England, the latter belting them by nine wickets after being set a paltry 154 to win.
Injuries have unsettled them, and the loss of Rohit Sharma after his 138 in their first game was a blow.
Aside from Sharma, India's batsmen have struggled in their first two matches.
MS Dhoni (53 runs at an average of 26.5) and Suresh Raina (52 at 26) are their top scorers.
Runs are much needed, and Virat Kohli needs to return to the form that saw him star in India's Test series loss to Australia.
Kohli has scored 13 runs in the tri-series so far, and more is expected of him.
India's bowlers have also had limited success, with only Umesh Yadav taking more than one wicket - he has two.
With the World Cup starting in mid-February in Australia and New Zealand, India desperately need to find some form.