Record-breaker Peyton Manning will undertake one of his biggest tests of the season when the Denver Broncos host the San Diego Chargers.
Manning last week set a new mark for the most touchdown passes in NFL history when surpassing Brett Favre to reach the hallowed 509th.
But attentions will quickly turn to week eight as the 5-1 Broncos tackle the 5-2 Chargers, who also have one of the game's star quarterbacks, Philip Rivers, in a crucial Thursday encounter.
That game begins an exciting week of action that will see a first as the Detroit Lions face the Atlanta Falcons at 9.30am eastern time.
The encounter, taking place at London's Wembley Stadium, will be the only one played during a time slot that has never before been utilised.
Detroit (5-2) are heavy favourites as they pit their wits against a team who have lost their last four encounters.
The London game kicks off a mouth-watering Sunday highlighted by the prime-time clash between two of the NFL's outstanding signal-callers.
But Aaron Rodgers, of the Green Bay Packers, and the New Orleans Saints' Drew Brees meet on the back of very different seasons so far.
While Rodgers' Packers are 5-2 on the back of four successive wins, the Saints are a miserable 2-4 following a last-gasp 24-23 defeat against the Lions last weekend.
However, there is still much for Brees and his team-mates to play for as they target the division title in a weak NFC South.
The earlier raft of Sunday games sees the Buffalo Bills and New York Jets meet in an all-AFC East clash, with the division's other teams, the New England Patriots and Miami Dolphins, tackling the Chicago Bears and Jacksonville Jaguars respectively.
The Baltimore Ravens will take on the Cincinnati Bengals in an AFC North meeting, while world champions Seattle Seahawks are attempting to bounce back from successive losses versus the Carolina Panthers.
The Minnesota Vikings travel to the Tampa Bay Buccaneers, the Houston Texans make the trip to the Tennessee Titans and the Kansas City Chiefs host the St. Louis Rams.
The best of the three later games sees 5-1 pair the Arizona Cardinals and Philadelphia Eagles meet, while the Indianapolis Colts travel to the Pittsburgh Steelers and the Cleveland Browns take on Oakland Raiders.
The weekend's action is rounded off by the season's surprise package Dallas Cowboys, who are 6-1, welcoming the Washington Redskins on Monday night.
The San Francisco 49ers and New York Giants are the only two teams on a bye.