Team captain McGinley confirmed his line-up for the event-opening fourballs on Thursday, with Rory McIlroy and Sergio Garcia set to go head to head with Phil Mickelson and Keegan Bradley, while Justin Rose and Henrik Stenson commence proceedings against Bubba Watson and Webb Simpson.
Rickie Fowler and rookie Jimmy Walker will face Thomas Bjorn and 2012 hero Martin Kaymer, and - in the remaining fourballs encounter - home favourite and rookie Stephen Gallacher is paired with Ian Poulter to take on Patrick Reed and Jordan Spieth.
But McGinley insists his team will not get carried away as Friday's first tee shot draws ever closer.
"We are very controlled and have got a big job ahead of us," he said. "We're very respectful of America and how strong they are going to be.
"They have a template with Bubba and Webb who have been very successful together in the past; and so have Phil and Keegan and he's gone one and four with them, and a very similar mindset to ours, which is obviously guys that are very low in world rankings at the top and bottom.
"We have some experience there in the middle, as well, and we have got a rookie in there in Stephen, and obviously put him with a very experienced player in Ian Poulter."
McGinley has chosen four unfamiliar pairings to get the event under way, but insists he had no qualms in doing so.
"These guys all know each other very well," he added. "You move forward, two years down the road, a different view and take on things, and games have evolved in slightly different ways and guys become more experienced.
"Ian Poulter is a very experienced player now. There's going to be a big atmosphere in that group. Obviously Stevie being Scottish, and the Ryder Cup being here in Scotland, it's going to bring a big atmosphere - we'll need a guy with a big attitude for that, and I think Ian Poulter fits that bill.
"Justin and Henrik spent a lot of time together at Lake Nona over the years, know each other very, very well.
"And you have Sergio and Rory who have formed a real bond and friendship and respect for each other's games, too, during the summer period. Things evolve and move. The template doesn't mean pairings have to be the exact same pairings."
Europe will be defending the title they won in dramatic circumstances at Medinah in 2012, when the visitors came from 10-4 down to triumph by a point.