The Dane was beaten in the Flushing Meadows decider by Serena Williams, who retained her number one mantle.
Wozniacki, though, saw her ranking into single figures for the first time in 2014, as she rose two spots to ninth.
Other movement inside the top 10 saw Petra Kvitova climb to third, and Maria Sharapova move fourth, as the inactive Li Na - sidelined by injury - slipped to sixth.
Agnieszka Radwanska held onto the fifth ranking, while Eugenie Bouchard (seventh) traded places with Angelique Kerber (eighth).
Serbia's Ana Ivanovic moved one spot down to 10th, while countrywoman Jelena Jankovic was bumped out of the top 10 and sits in 11th place.
New York semi-finalist Ekaterina Makarova climbed three places to 15th, a career-high ranking for the left-handed Russian.
Italy's Flavia Pennetta dropped points despite reaching the quarter-finals - she was a semi-finalist in 2013 - and as such, fell four spots to 16th in the world.
Australia's Sam Stosur climbed one spot to be back in the top 20, while just outside in 21st is US Open semi-finalist Peng Shuai, who shot up 18 places.
Last year's finalist in New York, Victoria Azarenka bowed out in the last eight this year and felt the full force in the rankings - dropping from 17th to 24th.
Belinda Bencic, the teenager from Switzerland, was another to benefit from her deep run at the major when she reached the last eight, climbing from 58th to 33rd.
The ATP World Tour's rankings have also been updated, despite the men's US Open final still to be played.
Finalist Kei Nishikori has moved three spots to eighth courtesy of his barnstorming run, but the Japanese star could be world number five with a win in the New York decider.
Nishikori still has to get past Croatia's Marin Cilic, who has risen four places to 12th - and could be inside the top 10 with a win on Monday.
The top five remained unchanged, while Czech Tomas Berdych (sixth) exchanged places with Canada's Milos Raonic (seventh).
Other notable moves inside the top 20 were those of Spain's Roberto Bautista Agut (up four to 15th) and France's Gael Monfils (up six to 18th).
Bautista Agut's new ranking is the highest of his eight-year professional career.