Fisch paid the price for Jacksonville's struggles offensively in 2014, with the Jaguars ending the NFL season with a 3-13 win-loss record.
The Jaguars were 31st in total offence, 31st in rushing and 22nd in passing.
Jaguars head coach Gus Bradley said the decision to axe Fisch after two years was down to "philosophical" differences.
Those differences were based on the increased workload on rookie quarterback Blake Bortles, who started 14 games and threw for 2,908 yards and 11 touchdowns - a single-season record for the Jaguars.
"There is a lot of truth now to philosophical differences as far as we want to put on Blake's plate to do a lot," Bradley told reporters.
"Lets throw a lot at him and then lets see how much he'll be able to carry that over to next year. Or, no, lets not put a lot on his plate and let him grow through this. Which way is best? I don't know. I know the way we kind of want to do it.
"I just think we want to help him get better every day and not overwhelmed. I think you know my philosophy enough of be careful of how much you put on a guy to create a lot of anxiety that might keep him from being his best."