Ligue 1 leaders Nice were knocked out, going down 3-2 to Bordeaux in their last-16 tie.
However, Ligue 1 leaders Nice were knocked out, going down 3-2 to Bordeaux in their last-16 tie.
At the Parc des Princes, PSG ended a three-match winless run as Unai Emery's men defeated Lille in a repeat of last season's final.
Lucas scored twice with a 43rd-minute penalty and a 57th-minute goal before young Spanish striker Jese made the most of just his second start to hit the third after 69 minutes.
"(Jese) progressed as the match went on and he scored," said Emery.
"It wasn't easy for him but he found his rhthym as the minutes passed. He needs to play, that is clear."
PSG will face Metz, who won a penalty shootout 11-10 against Toulouse, in the quarter-finals.
Title-chasing Monaco saw 17-year-old Kylian Mbappe hit his first professional hat-trick as the Principality side also made the quarter-finals.
Mbappe, who turns 18 on December 20, now has six goals for the season in all competitions.
Rennes will be fed up of the sight of the Stade Louis II where they lost 3-0 in a league game in September.
Jaroslav Plasil put Bordeaux ahead against Nice after 14 minutes while a 22nd-minute strike from Gaetan Laborde made it 2-0 before Alassane Plea pulled one back just before the interval.
Laborde restored Bordeaux's two-goal lead 10 minutes into the second period with Mario Balotelli's 83rd-minute penalty proving just a consolation for Nice who have already been eliminated from the Europa League this season.
Lyon also exited the tournament, losing 4-3 on penalties at home to Guingamp after a 2-2 draw in normal time where they twice came back from a goal down.
On Tuesday, Marseille crashed out after losing 4-3 on penalties to second-tier Sochaux following a 1-1 draw.
Bouna Sarr fired the three-time champions ahead at the Stade Bonal but Moussa Sao swiftly responded to level for hosts Sochaux.
Goalkeeper Christopher Dilo then saved spot-kicks from Doria and Aaron Leya Iseka in the shootout as Sochaux, the only non top-flight team left in the competition, advanced to the quarter-finals.
Portugal international Sergio Conceicao made a winning start as Nantes manager with a 3-1 victory over Montpellier.
Argentine striker Emiliano Sala struck either side of a Kevin Berigaud goal at the Stade de la Beaujoire.
Poland international Mariusz Stepinski added a third for Nantes on the hour, although the hosts played out the final few minutes with 10 men after the dismissal of Abdoulaye Toure.