Vidic joined Manchester United in January 2006 where he won five Premier League titles and a Champions League trophy
He made just made just 28 appearances for Inter Milan last season before he left the Serie A giants.
Also read: How Vidic left Inter Milan
It was reported that he was interested in a move to the MLS but in a statement released via the United website, Vidic said: "The time has come for me to hang up my boots. The injuries I have had in the last few years have taken their toll.
"I would like to thank all the players I have played with, all the managers and staff I have worked with, and say a big 'thank you' to the fans for their support over the years."
Nemanja Vidic career in brief:
Red Star (2001-04) – 95 apps 6 goals
Spartak Moscow (2004-05) – 41 apps 4 goals
Man United (2006-14) – 300 apps 21 goals
Inter Milan (2014-16) – 28 apps 1 goal
Serbia (2002-11) – 56 apps 2 goals
Watch this Nemanja Vidic's Manchester United highlights, below: