Barca have to win to have any chance of keeping the title alive ahead next weekend's Clasico againt Madrid.
Here, AFP Sports looks at five things to look out for in La Liga this weekend.
Barca's season unravelled quickly in the past week as they lost at Malaga to fall three points behind Madrid, who also have a game in hand, at the top of the table and were then thrashed 3-0 by Juventus in the Champions League.
In between Neymar was also slapped with a three-game ban following his first Barca red card last weekend and misses Real Sociedad's visit on Saturday, as well as a potential decisive clash with Madrid at the Santiago Bernabeu next weekend.
Barca have to win to have any chance of keeping the title alive ahead next weekend's Clasico but have been let down by their lack of strength in depth this season.
Boss Luis Enrique therefore has a delicate balance to find between resting some of his star names ahead of another Champions League rescue mission in midweek and still having enough to see off a Sociedad side battling for a place in the Europa League.
In stark contrast to Barca's troubles, Real Madrid have been propped up throughout the campaign by the depth of their resources.
No more so than by Marco Asensio. The 21-year-old made a huge impact by setting up Cristiano Ronaldo's winner against Bayern Munich on Wednesday after replacing Gareth Bale for the final half hour.
With Bale set to sit out the trip to Gijon, Asensio will get his chance to make a case to start against Bayern on Tuesday.
Tony Adams made a surprise return to coaching this week as Granada boss due to his close ties with the club's Chinese ownership.
The eccentric former Arsenal captain didn't disappoint in his first press conference where he promised to "kick some players' arse" in an uphill battle to save Granada from relegation in the final seven games of the season.
Adams takes charge for the first time against Celta Vigo on Sunday with Granada seven points adrift of safety.
The fight to be top dogs in the Basque Country will almost certainly be rewarded with a place in Europe with Sociedad, Athletic Bilbao and Eibar separated by just two points between sixth and eighth.
With Sociedad at the Camp Nou, Athletic can move a step ahead when they host Las Palmas on Friday night before Eibar continue their remarkable charge at struggling Betis on Sunday.
The population of Eibar would fit twice into Betis' Benito Villamarin stadium, yet they are 19 points ahead of the Seville giants thanks to an already record points tally of 50 in the top flight.
There is a rare sense of positivity around Valencia's fortunes at the minute after three consecutive wins for the first time in a year.
Chairwoman Layhoon Chan's resignation earlier in the week also pleased a large section of the fanbase unhappy with her role in a disastrous past couple of seasons on and off the pitch.
Sunday's visitors to the Mestalla should take note of what bad organisation from the top can do to even a historically big club.
Sevilla are in a state of flux after sporting director Monchi's departure and look set to lose coach Jorge Sampaoli to Argentina's advances at the end of the season too.
Fixtures (all times GMT)
Athletic Bilbao v Las Palmas (1845)
Deportivo la Coruna v Malaga (1100), Sporting Gijon v Real Madrid (1415), Atletico Madrid v Osasuna (1630), Barcelona v Real Sociedad (1845)
Leganes v Espanyol (1000), Valencia v Sevilla (1415), Real Betis v Eibar (1630), Granada v Celta Vigo (1845)