The Flying Eagles have an away goal advantage over Guinea Bissau ahead of the second leg.
Paul Aigbogun's team played the first leg of the qualification tie away at Guinea Bissau.
The Flying Eagles had a dominant first half and took a 2-0 lead before the break through a brace by Wasiu Alalade in the 15th and 35th minute.
The Guinea Bissau team that defeated Sierra Leone in the previous round responded in the second half in fron of their home supporters at the September 24 Stadium with two goals scored in the 54th and 63rd minute to get a 2-2 draw.
The result means the Flying Eagles have an away goal advantage going into the second leg encounter.
Captain Ikouwem Udoh will have to lead the Flying Eagles to avoid defeat in the return leg at home to qualify for the U-20 AFCON tournament which will be hosted by Niger in 2019.