Spartak Moscow and Lille were the high-profile casualties of Europa League qualifying, losing to Larnaca and Qabala respectively.
Russian Premier League giants Spartak Moscow were dumped out of the Europa League qualifiers after a shock defeat to Larnaca.
Spartak, quarter-finalists in the competition as recently as 2011 and champions of Russia on 21 occasions, suffered a 1-0 home defeat to last season's runners-up in the Cypriot top flight thanks to Ivan Trickovski's 89th-minute goal.
The result gave Lanarca a 2-1 aggregate victory to send them into Friday's draw for the play-off round.
Lille, who welcomed back Portugal's Euro 2016 hero Eder, were stunned by Azerbaijan outfit Qabala, who sealed a 2-1 aggregate win thanks to a 1-0 victory on home soil.
Filip Ozobic scored the only goal of the game 11 minutes before half-time to send the Ligue 1 side crashing out of European competition and see Qabala into the play-offs, where they will join compatriots Qarabag.
Hertha Berlin also suffered an early exit, with Teemu Pukki's hat-trick securing a 3-1 win for Brondby on Thursday and a 3-2 victory on aggregate.
Friday's draw will include sides dropping out of the Champions League qualifiers, with Shakhtar Donetsk, Fenerbahce and Anderlecht among them.