Sam Vokes scored twice as Burnley torpedoed defending champions Chelsea 3-2 at Stamford Bridge on Saturday in one of the most sensational opening-weekend results in English top-flight history.
Chelsea had captain Gary Cahill and Cesc Fabregas sent off and Burnley took full advantage through Vokes's brace and a superb Stephen Ward effort, with goals from Alvaro Morata and David Luiz coming in vain.
Leicester City lost 2-1 at Hull City on the first day last season, but given the unexpected nature of their title win, this was the biggest opening-day shock since Manchester United's 3-1 loss at Aston Villa in 1995.
"It was a pity because our fight in the second half was very good," said Chelsea manager Antonio Conte.
"But our first half, we kept losing our heads. After the red card we lost our heads, conceded two goals and then it's very difficult to change the final result."
Big-spending Manchester City won 2-0 at promoted Brighton and Hove Albion, while Huddersfield Town marked their top-flight return with a fine 3-0 win at Crystal Palace that sent them top of the table.
Burnley's win, their first at Chelsea since 1971, further blackened the mood around Stamford Bridge after a close season during which Conte has grown frustrated by his club's lack of transfer activity.
Conte was without the injured Eden Hazard and out-of-favour striker Diego Costa, while £58 million ($75.5 million, 63.8 million euros) signing Morata started on the bench.
Youth-team graduate Jeremie Boga made his debut, but was hauled off in the reshuffle that followed Cahill's 14th-minute dismissal for a studs-up foul on Steven Defour.
Vokes put Burnley ahead in the 24th minute, volleying in from Matthew Lowton's cross.
Ward doubled the visitors' advantage in the 39th minute with a blistering left-foot strike from Jack Cork's lofted pass and Vokes added a third before half-time, heading in Defour's cross.
Half-time substitute Morata and Luiz reduced the arrears in the second half, either side of Fabregas's 81st-minute dismissal for a second yellow card, but Burnley hung on for a famous victory.
"Did we expect this situation? No, if we're honest," said Burnley manager Sean Dyche.
"It was a fantastic three points and the referee, I just want to say, was fantastic today."
Manchester City manager Pep Guardiola had some £150 million of new recruits on display at Brighton, but it took the pre-season favourites until the 70th minute to take the lead.
David Silva fed Sergio Aguero to run through and beat goalkeeper Mathew Ryan and five minutes later Lewis Dunk headed Fernandinho's cross into his own net.
"We controlled the counter-attacks and we didn't concede one chance," Guardiola told BBC Sport.
"I was very happy with the new players. I want to say thank you to the club. We have huge players with lots of talent. Big congratulations to all the people in Manchester City -- we are a strong club."
Liverpool were denied a winning start as Miguel Britos claimed a contentious stoppage-time leveller to earn Watford a 3-3 draw at Vicarage Road.
Watford twice went in front through Stefano Okaka and Abdoulaye Doucoure, but Liverpool equalised each time via Sadio Mane and Roberto Firmino, who then teed up new boy Mohamed Salah to put the visitors 3-2 up.
In the third minute of injury time, a shot from Richarlison was pushed against the bar by Liverpool goalkeeper Simon Mignolet and Britos, who appeared to be offside, nodded the ball over the line.
"The equaliser was offside. It's obvious because the linesman is on the line. He needs to see it," said Liverpool manager Jurgen Klopp.
Frank de Boer made a losing start as Palace manager after a Joel Ward own goal and a Steve Mounie double earned Huddersfield a 3-0 win on their return to the top flight after an absence of 45 years.
Mounie's goals were the first repayments on his club-record £11.4 million transfer from Montpellier and sent the Yorkshire club to the top of the fledgling standings.
Wayne Rooney crowned his first appearance for formative club Everton since 2004 by notching the winner in a 1-0 win over Stoke City, heading in Dominic Calvert-Lewin's cross for his 199th Premier League goal.
Debutant Ahmed Hegazi's first-half header earned West Bromwich Albion a 1-0 win over Bournemouth, while Mauricio Pellegrino's tenure as Southampton manager began with a 0-0 draw at home to Swansea City.
Late goals from substitutes Aaron Ramsey and Olivier Giroud earned Arsenal a 4-3 win over Leicester in Friday's frantic opening game.