Musa was again on target to help his side cruise to a comfortable victory over their rivals at home.
The Nigerian forward who was awarded the in his last league outing continued his impressive performance for Al Nassr as he scored the games opener in the 26th minute.
Al Nassr were pegged back when Rodolfo de Almeida Guimaraes equalised for the away side in the 32nd minute as both sides went into the half time break level.
Ahmed Musa and his teammates however turned on the style with the Nigerian forward providing an assist as Al Nassr scored four second half goals to seal the victory.
Giuliano de Paula scored in the 47th and 57th minute in the second half to give Al Nassr a two goal cushion.
Morocco International Nordin Amrabat scored the fourth in the 74th minute before Mohammed Al-Sahlawi made it five in the 79th minute as Al Nassr continued their unbeaten run in the league.
Musa is expected to depart for the Super Eagles 2019 Africa Cup of Nations (AFCON) double header qualifier against Libya which he will be captain in absence of Mikel Obi.