She had been suffering from congestive heart failure and chronic obstructive pulmonary disease before she finally passed.
She was 92 years old.
Barbara's death was announced by her husband, George H.W. Bush, the 41st president of the United States.
She had been suffering from congestive heart failure and chronic obstructive pulmonary disease before she finally died.
Barbara had rejected further medical treatment following series of hospitalizations, including one in early 2017 when she and her husband were both patients at Houston Methodist Hospital.
She is the second woman in U.S. history to be a wife and mother of the country's president.
Abigail Adams, wife of John Adams and mother of John Quincy Adams, was the first US First Lady to hold a similar place in American history.
Barbara's son George W. Bush was sworn in as the 43rd president eight years after she and her husband left the White House.