The group accused the party of being responsible for thousands of Biafran deaths in its bid to stop the movement.
This is in response to the party's condemnation of IPOB leader, Nnamdi Kanu for his call on Anambra people to shun the November 18 gubernatorial election in the state.
The party deemed the call "irresponsible, irredentist and totally devoid of any focus."
IPOB's response was contained in a press statement released on Wednesday, June 28, 2017, by the group's media and publicity secretary, Emma Powerful.
The statement questioned the APGA's motivations for attacking its leader, saying unlike the group, it is "motivated by personal greed and self-aggrandizement".
The statement read, "The spurious and childish accusation that our leader Mazi Nnamdi Kanu who is also the Director of Radio Biafra and Biafra Television to stop parading himself as emperor smacks more of envy borne out of desperation than a reasoned assertion.
"There is no one more humble than the IPOB leader, that is why he is loved by millions, so the little anti-Biafra rant by APGA will only encourage us the more to ensure that the lockdown of Anambra State come 18 November 2017 is total and complete.
"We would prove to APGA that our leader Mazi Nnamdi Kanu has never in his life, since the inception of IPOB, indulged himself or arrogated any powers to himself.
"The perverse insinuation that he made himself a god is a clever ploy designed to appeal to the envious nature of certain individuals who wish to be like him but can never.
"It is insulting for a party that supervised the killing of thousands of IPOB family members, which they connived with the APC Government of Buhari to cover up, to be advising the same people they killed to turn against IPOB.
"History will remember the All Progressive Grand Alliance (APGA) as the party that murdered those that voted her into power."
The statement went further to accuse the party of being responsible for thousands of Biafran deaths in its bid to stop the movement.
"We the Indigenous People of Biafra and its leadership worldwide view the childish antics of the All Progressive Grand Alliance as a jealousy laden, derisory attempt to deflect attention away from the fact that APGA as the governing party in Anambra State has been responsible for the death of innocent Biafrans numbering over 2000 since the formation.
"The two notable instances being the infamous Ezu River bodies and the heinous massacres at Nkpor and Head Bridge Onitsha respectively.
"The party employed wholesale slaughter of their people as a way of stopping the agitation for restoration of Biafra not knowing that we are prepared to keep dying until Biafra is restored as we swore.
"In the purported letter written by the party in Anambra State threatening a showdown with IPOB led by Mazi Nnamdi Kanu which gave order of no election in all Biafra land starting from Anambra Gubernatorial election come November this year, APGA failed to mention the fact that Biafrans and IPOB in particular, campaigned and voted for both Peter Obi, Rochas Okorocha and Willie Obiano but were rewarded with shoot on sight orders issued by both men.
"It is very unfortunate that APGA as a political party preoccupied with feathering the nests of a select few, underestimate the desire of every genuine Biafran to be liberated from the slavery and bondage that Nigeria has come to represent.
"APGA is motivated by personal greed and self-aggrandizement unlike IPOB that is purely focused on the liberation of our people and by extension, other oppressed people in Nigeria," Powerful said.