Al Jazeera reports that, as of 4:55 GMT, Trump was leading Hillary Clinton by 23 electoral college votes, with a tally of 232-209. 270 votes are needed to win.
Dollar, global markets crash as Trump looks set to win US election
US stock futures dropped by more than 4 percent, similar to what happened when the British voted to leave the European Union in June.
The Mexican peso also went into near freefall when Trump won in the key state of Florida, dropping more than 10 percent against the dollar.
"There's a lot of panic in the market. It is definitely an outcome it was not expecting," Juan Carlos Alderete, a strategist at Banorte-IXE told Reuters news agency, according to Al Jazeera.
Global markets fear a Trump win could cause global economic and trade turmoil, a sentiment that is shared by the US Federal Reserve leading to the body refraining from raising interest rates.
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