After 10 years,
For the movie, Oboli takes up the role of Ebere, an unhappy wife, who after a visit and prayer from a man of God, switches body with her husband, Toyosi.
It's her first body-swap role and the actress was scared when she saw the script for the first time.
"I was scared," she said to Pulse Nigeria.
"I thought to myself, 'I have never been a man before. How am I supposed to be a man? I don't even know how to be a man.'
"But I thought it was really challenging. I thought it was something I would love to do in my career at this time; to play a role that totally takes me away from myself."
"It's hard enough being a female lawyer because I'm not a lawyer, but then being a man is totally off what I'm used to.
So, I thought it was going to be really challenging for me and I wanted to take up that challenge, and I did. And I thought I did a pretty good job."
On how confusing it was being both a man and a woman;
"It was quite confusing because I had to be a woman at some point, and I had to be a man at some other point," she said.
"And you know that when you're shooting, you don't shoot linearly. So you have to always remember that 'oh, I'm still Ebere in this scene and I'm now Toyosi in this scene.
So, it was quite confusing many times, but we pulled through."
On how much fun it was portraying a couple trapped in each other's body
"We did have a lot of fun on set and there were so many moments [memorable]. A lot of the scenes Ramsey and I had in the bedroom were really funny. Even the crew members were laughing.
Ramsey and I are friends, so we are quite comfortable with each other. We would tease each other, it was really fun."
On what makes "My Wife and I" different and special
"The script is a very big part of it, you know I have really never done any swap role before, but then it was directed by a very young female filmmaker," she said.
"It was a lot of fun, she is young, It's her first feature film. She knew what she wanted. It was just fun watching her do her thing. I was so impressed."
The star of the upcoming comedy movie also revealed that the box office hit "Wives on Strike" is returning as a TV series and a sequel.