There were divided views over the title, which is Aniston's second, having already won the recognition in 2004.
The announcement was made on Wednesday, April 20, 2016, and as can be expected, there are divided opinions concerning if she merits the title.
Aniston appeared on the cover of the widely read magazine with her honorary title boldly written.
This is the second time the ‘Friends’ actress has received the recognition. She was voted as the most beautiful woman in 2004.
The discussion will be incomplete without some fans throwing shades, would it?
Some fans revealed that disagreement with People Magazine's choice in naming the actress for the title.
One fan wrote, "Jennifer Aniston is NOT the most beautiful woman. Not even."
Reacting to the title while speaking to People, Aniston said, "I thought, 'Oh my God,”.
"There was this sort of very excited, teenage-y kind of moment."
Jennifer Aniston, who has had a wonderful acting career takes over the crown from fellow actress, Sandra Bullock, who was the winner for 2015.
See more about Aniston below.