Two explosions struck the Al-Balili mosque as worshippers were performing prayers for the Eid al-Adha festival.
ISIS bombs Yemen Mosque during Eid prayers
Officials have confirmed 29 people dead with hundreds severely injured.
CNN reports that the terrorist group ISIS claimed responsibility on social media for the bombing.
ISIS posted the statement on Twitter and said the bombing came as "part of a series of military operations to revenge Muslims against Houthis."
Houthi rebels are acting as the government in Yemen, having driven the internationally recognized government out of power.
The early morning prayer service was meant to mark the beginning of Eid al-Adha, which commemorates the prophet Abraham's willingness to sacrifice his son for God. The holiday is one of two major ones in Islam.
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