"This motherf---er is like ruining the planet and all kinds of other crazy s---," Jackson said. And if you're not saying anything, then you're complicit. And I wouldn't give a f--- if I was a garbageman and I had a Twitter account; I'd tweet that s--- out.
"I'm not thinking about who I am and what my job is when I do that s---."
Jackson, who has been a frequent critic of President Donald Trump and Republican lawmakers, was asked if he worries about "antagonizing fans" with his ideology.
"I know how many motherf---ers hate me. 'I'm never going to see a Sam Jackson movie again.' F--- I care? If you never went to another movie I did in my life, I'm not going to lose any money. I already cashed that check. F--- you. Burn up my videotapes. I don't give a f---," he said.
Jackson also mocked the common idea that actors should "stick to acting" and shut down the idea that, as a rich celebrity, he's not affected by governmental action.
"I'm a human being that feels a certain way," he said. "This is how I feel. And I count to 100 some days before I hit 'send,' because I know how that s--- is."
As Esquire notes, Jackson has starred in 120 movies over the 40-year span of his career. He has claimed some of the most coveted and respected roles in history, from Jules in "Pulp Fiction" and Mace Windu in "Star Wars" to his current stint as S.H.I.E.L.D. agent Nick Fury in the Marvel behemoth.
Before finding fame, Jackson was raised in the segregated South and later became an active participant in the '60s civil rights movement.
"I'm the same cat. I still got my politics. I still have my anger," he told Esquire.
