The announcement came a month after del Potro staged an incredible comeback against
"Juan Martin del Potro has confirmed he will withdraw from the Australian swing due to fitness issues," the Classic organisers said in a statement, referring to the two tournaments in January.
"Del Potro confirmed via his management team overnight that he has not had sufficient recovery time and will be withdrawing from the (Auckland) Classic and the Australian Open."
The announcement came a month after del Potro staged an incredible comeback to down world number six Marin Cilic of Croatia in an epic five-setter to set Argentina up for their first Davis Cup crown.
Del Potro was the 2016 tennis comeback success story.
After missing most of last year because of injury, he began 2016 ranked 1,042th and finished at 38th after a meteoric rise which included wins over Stan Wawrinka, Novak Djokovic, Rafael Nadal and Andy Murray.
The 1.98 metre (6ft 6in) del Potro beat Roger Federer in the final of the 2009 US Open and the following year reached a career high of world number four before he began to be troubled by wrist injuries.
Auckland Classic director Karl Budge said it was disappointing for tennis "that these ongoing issues are keeping him off court".