Both sides are desperate to re-establish themselves among the top echelons of the Test game.
Both sides are desperate to re-establish themselves among the top echelons of the Test game, having failed to make a major impression in the latter half of 2016.
Argentina ended a run of four successive defeats with a comfortable 54-20 win over Japan in Tokyo last week.
In the process, the Pumas overtook Wales in World Rugby's global standings, moving up to sixth place from ninth position.
Meanwhile, Wales continued their slide since finishing second in the Six Nations as their losing run worsened with a thumping defeat by Australia last week their fifth loss in a row.
Wales know the importance of being among the world's top eight teams after finding themselves ninth in the rankings at the end of 2013, which led to them being drawn in the same World Cup pool as hosts England and Australia.
They escaped the group after beating England but losing to Australia only to be knocked out in the quarter-finals by South Africa.
"World rankings is a big motivation," said Wales flanker Sam Warburton.
"We fell out of the top eight back in 2013, just before the pool draw for the World Cup, and we ended up in a really tough pool, so we want to make sure that doesn?t happen again.
"Ideally we would be chasing a place in the top four but I don't know how realistic that is after last week. But we certainly want to finish as high as possible ahead of the draw (for Japan 2019).
First though, Wales must recover from last week's distressing 32-8 defeat by the Wallabies where, in front of their own fans at Cardiff's Principality Stadium, they were simply outclassed.
British and Irish Lions centre Jamie Roberts was the highest profile casualty of six changes made by interim Wales coach Rob Howley.
Scott Williams, a try-scorer last week, is preferred as midfield partner to Jonathan Davies who is one of three Lions back in the side.
Veteran lock Alun Wyn Jones plays for the first time since the death of his father, while Warburton came through his return to match fitness with club side Cardiff Blues last week.
Warburton is back in the team without the captaincy or in his usual position.
Justin Tipuric remains at openside while Gethin Jenkins retains the captaincy on a day when he will become the most-capped prop in world rugby, playing his 133rd Test for Wales and the Lions.
"It's something I will acknowledge after Saturday but this week is not about me, it's about the team delivering a performance we can be proud of because all the players are hurting after last week," said the 35-year-old Jenkins.
Argentina have made three changes from their victory over Japan, with centre Juan Martin Hernandez, wing Ramiro Moyano and back-row Pablo Matera replacing Jeronimo de la Fuente, Santiago Cordero and Tomas Lezana respectively.
Pumas coach Daniel Hourcade fears a Welsh backlash having been in charge for the last meeting between the teams when Argentina were beaten 40-6 in Cardiff three years ago.
"We are really motivated to face a hard team that have a lot of pressure after a bad game last week," he said.
"It's not the best time to play them. We would prefer to face a Welsh team in a better moment, not after a thrashing.
"It was a tough day last time we played them. After that tour, we started as a new team and we've seen a huge development in the players since then."