Zlatan Ibrahimovic will miss Paris Saint-Germain's Ligue 1 clash with Caen on Wednesday due to a heel injury.
PSG visit Caen hoping to get back to winning ways after being held to three consecutive draws in what has been a stuttering start to the new season.
However, the French champions will be without star striker Ibrahimovic for the trip to Normandy after tests revealed that the Sweden captain will require treatment for at least a further 48 hours.
A statement on PSG's official website read: "Because of a left heel pain and following examinations performed today [Tuesday], Zlatan Ibrahimovic is out for the match at Caen. His condition requires a minimum of 48 hours of care."
Although Ibrahimovic has struggled so far this season, the news that the 32-year-old misses out will come as a significant blow to a team that has found it difficult to see teams off in the early part of the campaign.
Ibrahimovic was visibly off-colour in last Sunday's 1-1 draw with Lyon, however, Blanc was quick to defend the former Barcelona, Milan and Juventus man in his pre-match press conference ahead of the meeting with Caen.
"I have always said that Zlatan is an important player in the squad. He is a leader of PSG. That's all I need to say," Blanc said.
"He has been through a difficult time. We need to help him and put him in the best conditions to perform. Because he is an important player. We saw last year what he is capable of."
There has been some speculation regarding coach Laurent Blanc's future in the aftermath of the stalemate with Lyon, although club president Nasser Al-Khelaifi has insisted the former France boss' position is not in danger.
Blanc concedes that his side have not been at their best so far this term, but stressed that their disappointing early form will not change the philosophy of the team.
"Our early season form is neither disastrous nor good," Blanc said. "We're missing something but not much.
"We will go to Caen with the same philosophy, with the same mindset that has been displayed since the beginning of last season."