Nikolai Topor-Stanley could make his first Australia appearance in more than six years after winning selection in Ange Postecoglou's 23-man squad.
The return of Topor-Stanley headlined the announcement on Thursday, with uncapped Sydney FC forward Bernie Ibini also included.
Skipper Mile Jedinak and veterans Tim Cahill and Mark Bresciano will provide the experience in a youthful squad that will play friendlies against the United Arab Emirates and Qatar next month.
Aston Villa utility Chris Herd - on loan at Bolton - and new Fiorentina signing Joshua Brillante were picked by Postecoglou, with the likes of youngsters Brad Smith, Massimo Luongo and Tomi Juric also involved.
Western Sydney Wanderers captain Topor-Stanley has been rewarded for his impressive club form with a return to the national fold, having not featured for his country since the 2008 Beijing Olympics.
The 29-year-old has made just three senior appearances for Australia " the last of which came in June 2008 against China.
Commenting on the squad, Postecoglou said it was slightly experimental but that he wanted to give more players a chance to shine as Australia's preparations for the 2015 Asian Cup continue.
"We are still giving players we've identified for the national team an opportunity to experience international football to ensure we create a deeper pool of players to call on for the Asian Cup and beyond," he said.
"These two games give us a few more to throw into the mix with an experienced core group of players to see how they cope with the training intensity and the demands of international football before we start monitoring them all leading into the Japan match.
"We will be in a position to select a settled squad for the Japan match in November, which will offer a strong indication of where we are at leading into the Asian Cup although players can always come into the squad with strong form and fitness at club level."
Australia play the UAE in Abu Dhabi on October 10 before facing off against Qatar four days later.
The matches clash with the first week of the A-League season and Postecoglou said he had that in mind when naming his squad.
"We were mindful that the matches coincide with the first weekend of the A-League and we tried to not be too disruptive but ultimately this is our national team and everyone agrees this is the highest honour in the game and we will always pick players deserving of that honour," he added.
Australia squad: Adam Federici, Mitchell Langerak, Mat Ryan; Aziz Behich, Jason Davidson, Ivan Franjic, Chris Herd, Trent Sainsbury, Brad Smith, Nikolai Topor-Stanley, Alex Wilkinson; Mark Bresciano, Joshua Brillante, James Holland, Mile Jedinak, Massimo Luongo, Mark Milligan, Tommy Oar, James Troisi; Tim Cahill, Bernie Ibini-Isei, Tomi Juric, Mathew Leckie