Chan will face off in Group G against World Cup-winning Brazilian coach Luiz Felipe Scolari and his Guangzhou side.
Chan will face off in Group G against World Cup-winning Brazilian coach Luiz Felipe Scolari and his Guangzhou side, who will be gunning for their third Champions League title in five years.
They are joined in the group by Suwon Samsung Bluewings of South Korea and a yet-to-be determined Japanese club.
In her debut season, Chan, 28, led Eastern Sports Club to Hong Kong's Premier League title in April for the first time in 21 years.
That earned her a Guinness World Record as the first woman coach to win a men's championship title in a top national football league.
In a tough Group H, defending Champions League winners Jeonbuk Hyundai Motors were drawn with A-League champions Adelaide United and Jiangsu FC of China, according to the group-stage draw announced at AFC headquarters in Kuala Lumpur.
UAE powerhouse Al Ain, last year's runners-up, will begin their campaign from Group C alongside formidable foes Al Ahli FC of Saudi Arabia, Iran's Zobahan FC, and the winner of a play-off between Qatar's El Jaish SC and FC Bunyodkor from Uzbekistan, the AFC said.
The group stage runs from February to May, followed by the knockout phase, with the final set for November of next year.
Group A: Al Ahli FC (UAE), PFC Lokomotiv (UZB), Al Taawoun (KSA), Playoff winner
Group B: Esteghlal Khouzestan FC (IRN), Al Jazira (UAE), Lekhwiya SC (QAT), Playoff winner
Group C: Al Ahli Saudi FC (KSA), Zobahan FC (IRN), Al Ain FC (UAE), Playoff winner
Group D: Al Rayyan SC (QAT), Al Hilal SFC (KSA), Persepolis FC (IRN), Playoff winner
Group E: Kashima Antlers (JPN), Muangthong United (THA), Playoff winner, Playoff winner.
Group F: FC Seoul (KOR), Japan 2nd Club (JPN), Western Sydney Wanderers (AUS), Playoff winner
Group G: Guangzhou Evergrande FC (CHN), Suwon Samsung Bluewings (KOR), still-undetermined Japan Club, Eastern SC (HKG)
Group H: Adelaide United (AUS), Jiangsu FC (CHN), Jeonbuk Hyundai Motors FC (KOR), Playoff winner