The actress died in the early hours of Thursday, February 18, after battling stage IV lung and brain cancer.
Her friend Vinnie Medugo confirmed via the star's Twitter account, on behalf of her family.
According to Medungo, Big Ang, real name Angela Raiola, passed away at 3:01 a.m., surrounded by friends and family.
"It is with sad regret that we inform you that at 3:01 a.m. Angela Raiola peacefully ended her battle with cancer, and was called home," the message on Twitter reads.
"She was surrounded by nothing but love from her immediate family, and closest friends. YOU, (Her fans) were some of the most special people in the world, and she loved you immensely."
"Thank you for your love, prayers, and unconditional support of Angela right to the very end. She truly went out richer than any monetary value could ever amount to. The family asks for privacy, and peace during this most difficult time. In typical Big Ang fashion, we know she would say 'Love you my babies!' This page will remain open as a celebration of who she was and will always be. It has been my esteemed privilege and honor to represent her in the highest regard via social media. Vinnie Medugno."
Raiola was diagnosed with throat cancer last year in March after doctors discovered a lemon-sized tumor. After two surgeries, she thought she was in the clear only to be diagnosed later with stage IV lung and brain cancer.