The televised bash from Los Angeles, which kicks off at 5 pm (0100 GMT Monday), could also have political fireworks as many artists are outspoken critics of US President Donald Trump.
But the enduring picture from the Grammys may turn out to be Beyonce, who is expected to make her first public appearance since revealing that she is pregnant with twins.
Beyonce leads the Grammys with nine nominations and could win the most prestigious awards for the first time -- Album of the Year for "Lemonade" and Record of the Year for her song "Formation."
"Lemonade," which Beyonce intertwined with a film, marked a new direction for the pop superstar as she dabbled in hip-hop, hard rock and even country.
"Formation" was the most politically upfront song of Beyonce's career with a video rallying behind the Black Lives Matter movement, including an image of police officers surrendering as if under arrest.
Throughout "Lemonade," Beyonce directed herself to an audience of fellow African American women with themes of resilience. In the film, she strongly suggested that her husband, rapper Jay Z, had been unfaithful but Beyonce by the end forgave him.
Beyonce faces competition in the main categories from Adele, who proved her enduring, massive commercial popularity by sticking to her style of wrenching ballads.
Return to stage for Adele
The English singer is nominated for her ubiquitous song "Hello" and her album "25," which has been the world's top-seller since her "21," which also triumphed at the Grammys.
Adele is scheduled to sing at the Grammys -- a year after her performance was marred by a falling microphone, which hit the piano and caused her voice to veer jarringly out of tune.
Other artists who stand a chance to win the most Grammys include Toronto rapper Drake, R&B superstar Rihanna and the hip-hop celebrity fixture Kanye West.
Drake has been nominated for "Views," his blockbuster collection of dance-ready tracks, and for "Work," his lusty collaboration with Rihanna.
Dark horses for Album of the Year include "A Sailor's Guide to Earth" by Sturgill Simpson, who has given some intellectual heft to country music through lyricism inspired by Buddhist philosophy.
Justin Bieber was nominated for "Purpose," in a surprise nod for the Canadian singer often more associated with tabloid exploits.
Chance the Rapper, 23, is a favorite to win Best New Artist amid acclaim for his gospel-infused hip-hop. The Chicago artist benefited from updated rules that consider streaming exclusives.
Tributes to late stars
The Grammys will feature tributes to two pop icons who died in the past year -- Prince and George Michael.
The performance is expected to herald the arrival of Prince, who battled the music industry for much of his career, to major streaming services following deals with his estate.
Katy Perry, back from a short hiatus in which she recorded new music, will use the global television platform to perform "Chained to the Rhythm," her retro disco-inspired new single.
Perry -- who with 95 million followers is the most popular person on Twitter -- released the song Friday after a unique social media campaign in which she sent fans around the world hunting for disco balls that held recordings of the single.
The show will also see the return of Daft Punk, the reclusive, robot-clad French electronic duo that has not performed in public since the Grammys in 2014.
Daft Punk will play with R&B sensation The Weeknd, whose music the duo recently produced. Daft Punk kicked off the weekend by opening a pop-up store in Los Angeles, although the duo has been characteristically tight-lipped on whether it plans more music or touring.
Lady Gaga -- who a week ago put on a riveting performance before more than 117 million television viewers at the Super Bowl halftime show -- is set for one of the more unlikely Grammy collaborations as she takes the stage with Metallica.
Gaga and Perry were among the most outspoken celebrity backers of Hillary Clinton in her campaign against Trump, raising the prospect of political statements at the Grammys.
But Gaga only addressed politics subtly at the Super Bowl as she championed a message of inclusion.
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